Studies on malabsorption in malnourished Pakistani children.

Malnutrition is a common finding in Pakistan especially in children of low socio-economic class. Impairment of digestion and absorption makes the diet inefficient at fulfilling the requirements of the child and leads to malnutrition. Earlier work from this laboratory has shown that feeding a high-protein diet to children suffering from protein-energy malnutrition (PEM) did not improve their condition. In the present study forty-two malnourished children and seventeen control subjects were investigated. They were divided into five groups, i.e. fibrocystic disease of the pancreas (n = 9), coeliac disease (n = 17), lactose intolerance (n = 5), PEM (n = 5) and nonspecific diarrhoea (n = 6) on the basis of history, clinical impression and biochemical findings. They were from 6 months to 12 years of age. The majority of them were suffering from diarrhoea, distension of the abdomen and retardation of growth. All children were physically examined and anthropometric measurements were recorded. Changes in hair in the form of sparseness, dyspigmentation and easy pluckability were observed in all groups. In PEM, 80% of the cases had enlarged livers. All children had reduced weight and height as compared with the control group. Haemoglobin, total protein and serum albumin showed a decrease and the fall was greatest in PEM cases as compared with the control group. The excretion of alpha-amino nitrogen increased in PEM children while hydroxyproline and creatinine levels showed a decrease as compared with the control group. The hydroxyproline index, which signifies the growth rate, was also significantly lower in all groups. Xylose and lactose tolerance tests were performed after an oral dose of xylose or lactose respectively. The xylose concentration after the test dose was reduced with the lowest values in the coeliac disease group as compared with the control group.(ABSTRACT TRUNCATED AT 250 WORDS)